Please contact Dr Michael F O'Neill for copies of these recent articles should they be of interest. You can also download free PDF files where available:

Antidepressant Drug Development

• Axford L, Boot JR, Hotten TM, M Keenan, F M. Martin, S Milutinovic, N A Moore, MF O'Neill, IA. Pullar, DE Tupper, K Van Belle, Vivien V (2004)
  Axford et al (180k PDF)
  Bicyclo[2,2,1]heptanes as Novel Triple Reuptake Inhibitors for the Treatment of Depression.
  Bioorg Chem Synth Lett. 13, 3277-3280.

Animal Models of Depresssion

• O'Neill MF and N A Moore (2003)
  Animal Models of Depression: Are there any? (151k PDF)
  Human Psychopharmacology, 18, 239-254.

Novel Treatments for Parkinson's Disease

• Correa M, A. Wisniecki, A. Betz, D.R. Dobson, M.F. O'Neill, M.J. O'Neill, and J.D. Salamone (2004)
  Correa et al (248k PDF)
  The adenosine A2A antagonist KF17837 reverses the locomotor supression and tremulous jaw movements induced by haloperidol in rat: possible relevance to Parkinsonism.
  Behavioural Brain Research 148, 47-54.

Recovery of function following brain damage

• Gilmour G, Iversen SD, O’Neill MF and Bannerman DM (2004)
  Gilmour Endothelin 2004 (292k PDF)
  The effects of intracortical endothelin-1 injections on skilled forelimb use: Implications for modelling recovery of function after stroke.
  Behavioural Brain Research. 165, 98–109.
• Gilmour G, Iversen SD, O'Neill MF, O'Neill MJ, Ward MA, Bannerman DM (2005)
  Gilmour et al 2005 (312k PDF)
  Amphetamine promotes task-dependent recovery following focal cortical ischaemic lesions in the rat.
  Behavioral Brain Research. 150, 171-183.

Early Preclinical Research on Glutamatergic Targets

• O'Neill  MF, Heron-Maxwell CL, Conway MW, Monn JA, and  Ornstein PL (2003)
  O’Neill et al (2003) mGlu2 antag (232k PDF)
  Group II metabotropic glutamate receptor antagonists LY341495 and LY366457 increase locomotor activity in mice.
  Neuropharmacology, 45, 565-574.

• O'Neill MF, Sanger G, Ornstein PL, Osborne DJ, Woodhouse SM (2005)
  O’Neill et al AMPA Locomotion 2005 (192k PDF)
  Locomotor activity detects subunit-selective effects of agonists and decahydroisoquinoline antagonists at AMPA/kainic acid ionotropic glutamate receptors in adult rats.
  Psychopharmacology, 179, 181-188.

Regulatory Affairs

• O’Neill MF and McGettigan G (2005)
  1 EMEA Intro 2005 (116k PDF)
  10 year of EMEA: CNS Medicines.
  Regulatory Rapporteur, 2, 9, 2-5.
• O’Neill MF (2005)
  2 EMEA Antipsychotics 2005 (408k PDF)
  10 year of EMEA: CNS Medicines 2: Antipsychotics.
  Regulatory Rapporteur, 2, 11, 21-26.
• O’Neill MF (2006)
  3 EMEA Alz 2006 (124k PDF)
  10 year of EMEA: CNS Medicines 3: Anti-dementia treatments.
  Regulatory Rapporteur, 3, 1, 12-19.
• O’Neill MF (2006)
  4 EMEA Duloxetine 2006 (240k PDF)
  10 year of EMEA: CNS Medicines 4: Duloxetine: A novel antidepressant.
  Regulatory Rapporteur 3, 3, 10-18.
• O’Neill MF (2006)
  5 EMEA Sonata/Zerene 2006
  10 year of EMEA: CNS Medicines 5: Sonata/Zerene (Zaleplon) a rapidly acting sleep-inducing agent.
  Regulatory Rapporteur, 3, 5, 8-12.